Located in the heart of Rhodes, the Semiramis Hotel Rhodes is near the walls of the medieval Old Town. Guests of this Rhodes hotel will be able to visit the Old Town area, as well as the many museums, and the harbor. Those staying at the hotel will find a number of shopping areas nearby, as well as places to dine and enjoy the nightlife. Located in the city, the Semiramis Hotel Rhodes is close to many popular attractions, many of which are within walking distance. Guests will be able to find public transportation that can take them to other areas they wish to visit. The airport is only 13 km from the hotel.

All of the rooms found at the Semiramis Hotel Rhodes feature wood furnishings and white décor. The rooms have air conditioning, dial up Internet access, cable TV, direct dial phones, tea and coffee making facilities, mini bars, work desks, and more.

Some of the amenities at the Semiramis Hotel Rhodes include an onsite restaurant that serves Greek and Mediterranean cuisine, a lounge bar, and a bar by the outdoor pool.